Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients
نویسندگان
چکیده
منابع مشابه
Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients.
Leptin is a powerful stimulant of ventilation in rodents. In humans, resistance to leptin has been consistently associated with obesity. Raised leptin levels have been reported in subjects with sleep apnoea or obesity-hypoventilation syndrome. The aim of the present study was to assess, by multivariate analysis, the possible association between respiratory centre impairment and levels of serum ...
متن کاملHyperleptinemia , respiratory drive and hypercapnic response in obese patients
Leptin is a powerful stimulant of ventilation in rodents. In humans, resistance to leptin has been consistently associated with obesity. Raised leptin levels have been reported in subjects with sleep apnea or obesity-hypoventilation syndrome. Objective: To assess by multivariate analysis the possible association between respiratory center impairment and levels of serum leptin. Methods: Three hu...
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Because abnormalities in cerebrovascular reactivity (CVR) in subjects with long-term diabetes could partly be ascribed to autonomic neuropathy and related to central chemosensitivity, CVR and the respiratory drive output during progressive hypercapnia were studied in 15 diabetic patients without (DAN-) and 30 with autonomic neuropathy (DAN+), of whom 15 had postural hypotension (PH) (DAN+PH+) a...
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INTRODUCTION The clinical course of patients with acute exacerbations of underlying COPD presenting with hypercapnic respiratory failure was reviewed. METHODS This was a retrospective review of 138 episodes of hypercapnic respiratory failure (PaCO(2) > or = 50 mm Hg and pH < or = 7.35). Patients were admitted to the West Los Angeles VAMC Medical Intensive Care Unit between 1990 and 1994. RE...
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1 Mokhlesi B, Kryger MH, Grunstein RR. Assessment and management of patients with obesity hypoventilation syndrome. Proc Am Thorac Soc 2008; 5: 218–225. 2 Subramanian S, Strohl KP. A management guideline for obesity–hypoventilation syndromes. Sleep Breath 1999; 3: 131–138. 3 Campo A, Frühbeck G, Zulueta JJ, et al. Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients. E...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2007
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00115006